Antihyperglycemic activity of eclipta alba leaf on alloxaninduced diabetic rats j ananthi et al yale journal of biology and medicine 76 2003, pp. The effects observed were compared with a known hepatoprotective agent, silymarin. Hepatoprotective effect of eclipta alba leaves has been seen in paracetamol induced liver toxicity in rats prabu et al. Haematological protective effect of raw extract and nano.
There are three kinds or eclipta albathe whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and. Hepatoprotective effect of wedelolactone against concanavalin. Evaluation of hepatoprotective activity of amoora rohituka. The objective of the present study was to evaluate the effect of eclipta alba l. Lal 1, amit kumar 1, prashant kumar 2, kuldeep singh yadav 3 1 department of pharmacy, sagar inst. Collect 250 ml of eclipta alba leaves juice, 50 ml. Phytochemical screening of methanolic extract and antibacterial activity of active principles of hepatoprotective herb, eclipta alba sunita dalala, sudhir k kataria b, kv sastry and svs ranac adepartment of biotechnology, kurukshetra university, kurukshetra6 119, haryana, india bdepartment of zoologybioscience, maharshi dayanand university.
This plant may be known by one or more common names in. Hepatoprotective activity of ethanolic extract of eclipta alba in. Jul 30, 2009 the activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. Since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry. Hepato protective activity of eclipta alba liver protective action phytochemical standardization hair growth promotion activity. Since the liver is involved in almost all biochemical processes and there are many different diseases that will affect it. Indigenous drugs are being constantly explored for this purpose. Hepatoprotective effects of eclipta alba on subcellular levels in rats. Narendra kumar paliwal tutor in pharmacology, department of pharmacology, govt. Sitha institute of pharmaceutical sciences 2, hyderabad, andhra pradesh, india.
Collect 250 ml of eclipta alba leaves juice, 50 ml of amla juice, 50 ml of garlic juice and mix them. Oct 29, 2014 an alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. Eclipta alba bhringraj benefits and usages ayurveda. The wide range of compounds showing antiulcer and hepatoprotective effect, among them flavonoids is most important. In indian systems of medicines herbal decoction of eclipta alba. Andrographis paniculata, eclipta alba, picrorrhiza kurroa, silibum marianum, phyllanthus and trichopus zeylanicus, etc. Some study showed that hepatoprotective activity of the extract of e. Wo2011074001a2 a hepatoprotective herbal composition. The study was designed to evaluate the hepatoprotective activity of p. Methanolic extract and active principle compound of a well known indian hepatoprotective herb, eclipta alba was tested for in vitro antimicrobial studies.
Dec 30, 2015 hepatoprotective effect of enicostemma littorale blume. There are no known side effects with this medicine in its regular dose. There was decreased activity of glucose6 phosphatase and fructose1,6bisphosphatase, and an increase in the activity of liver hexokinase. The present study was designed to compare the probable hepatoprotective activity of olive oil and n. The maintenance of a healthy liver is vital to overall health of the human beings. The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Visited 467 times, 1 visits today downloads pdf downloads. It is whole plant of eclipta alba belonging to family compositae. Ethnopharmacological significance of eclipta alba l. Hepatoprotective effect of poly herbal formulation against various hepatotoxic agents in rats. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of. Eclipta alba false daisy is a herb that has traditionally been used in ayurvedic medicine for being a liver tonic for which it is one of the more effective herbs apparently and having beneficial effects on diabetes, eye health, and hair growth in regards to these claims, it appears to have some antidiabetic effects in animal studies with the mechanism of action not yet known.
It is known in the three major forms of traditional medicinal systems in the indian subcontinent, namely, ayurveda, unani. The current study aimed to investigate the hepatoprotective effect of wedelolactone, a major coumarin ingredient of eclipta prostrata l. Eclipta alba extract with potential for hair growth. The alcoholic extract has shown antiviral activity against ranikhet disease virus. This wonderful plant may be found as an erect or prostrate with many branches having roughly hair. The liver is often abused by environmental toxins, which are eating habits, alcohol and overdose of certain drugs which can damage and weaken the liver and eventually lead to many diseases. Evaluation of hepatorenal and haematological protection of. Dnadamaging steroidal alkaloids from eclipta alba from.
Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal. The protective effect of the plant against carbon tetrachlorideinduced acute liver dam age has been reported 3. Comparative study on hepatoprotective activity of aegle. Jan 14, 2019 in vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Agrawal, hepatoprotective activity of emebelia ribes against paracetamol induced acute hepatocellular damage in mice, experimental medicine, 2003, vol. This plant may be known by one or more common names in different places, and some are listed above. Hepatoprotective activity extensive research corroborates the hepatoprotective activity of eclipta alba. There are also reports of clinical improvement in the treatment of infective hepatitis.
Mode of antibacterial activity of eclalbasaponin isolated from eclipta alba. Ea significantly counteracted ccl 4induced inhibition of the hepatic microsomal drug metabolising enzyme amidopyrine ndemethylase and membrane bound glucose 6phosphatase, but failed to reverse the very high degree of. Rajakumar and abdul rahuman 2011 investigated the larvicidal activity of synthesized agnps produced by aqueous extract of eclipta prostrata, a member of the asteraceae. It is a seminar on hepatoprotective drug authorstream presentation. Hepatoprotective activity of eclipta alba is well described in literature 33, 3538. Pharmacological activity and chemical constituents of ecliptaalba. The acute toxicity studies have shown that like ea, fraction eaii also high safety margin. Boerhaavia diffusa, eclipta alba, picrorrhiza kurroa, cichorium intybus and tinospora. Eclipta alba has been used in traditional and folklore medicine to treat. Abstract eclipta alba is a herb commonly found throughout india. The protective effect of the plant against carbon tetrachlorideinduced acute liver damage has been reported 3. The methanolic extract of fresh leaves of the plant eclipta alba ea was known to produce hepatoprotective activity. Eclipta prostrata an overview sciencedirect topics. Antifungal activity of eclipta alba metabolites against.
Comparative hepatoprotective activity of three phyllanthus. Eclipta alba definition of eclipta alba by medical. Mohammed ishaq 3 deccan school of pharmacy 1, hyderabad, andhra pradesh, india. Review on some medicinal plants with hepatoprotective. U 405 international journal of environmental sciences volume 2 no. It is regarded as a weed of ethnomedicinal significance. There are three kinds or eclipta alba the whiteflowering, the yellowflowering, and the blackfruiting, but all three grow throughout india by marshes, rivers, and lakes or on the foothills of the himalayas.
Comparative study on hepatoprotective activity of aegle marmelos and eclipta alba against alcohol induced in albino rats arun. Bhringraj is a widely celebrated medicinal plant, especially in india, used singly or in combination with other herbs such as amala, shikaakai for making a vast range of hair care, hair rinse and conditioner products. The heptoprotective of the study confirmed the hepatoprotective activity of aqueous extracts of e. Antibreast tumor activity of eclipta extract invitro and in. It is used in medicines of pediatric conditions and in lactating mothers. Aerial parts of eclipta alba are used traditionally for the treatment of several diseases of liver, skin and stomach. Alcoholic extract of eclipta alba shows in vitro antioxidant and. The present invention provides a herbal composition comprises potent liver specific herbs which improves the liver function and also helpful in cleaning the toxic accumulations and detoxifying poisons in liver. Antibreast tumor activity of eclipta extract invitro and invivo. It is a weed which grows in tropical and subtropical regions all over the world. The fresh plant is used as self medication by aids. Hepatoprotective activity of eclipta alba pdf indian j physiol pharmacol. Indian journal of physiology and pharmacology, 45, 435441.
Effect of aegle marmelos and eclipta alba leaves extract on the leaves of aegle marmelos and eclipta alba. Article received on 12012017 article revised on 03022017 article accepted on 25022017 description of eclipta alba linn. Evaluation of hepatorenal and haematological protection. Read comparative hepatoprotective activity of three phyllanthus species, p. Eclipta alba extract with potential for hair growth promoting.
Among the two plants aegle marmelos has slightly high activity as compare to eclipta alba. Gujerati bhangro, dadhal, kalobhangro canarase ajagara, garagadasoppu, kadiggagaraga marathi bhangra. A major project report on evaluation of hepatoprotective activity of amoora rohituka submitted to rajiv gandhi proudyogiki vishwavidyalaya in partial fulfillment of the requirement for degree of master in pharmacy pharmacology, bhopal submitted by shailly malviya supervisor cosupervisor dr. Eightyone wistar albino rats were divided into four groups. Wagner h, geyer b, kiso y, hikino h, rao gs 1986 coumestans as the main active principles of the liver drugs eclipta alba and wedella calendulaceae. Using the wellestablished animal model of concanavalin a. Ethanolic extract of eclipta alba eeea was evaluated for memory enhancing activity using. The hepatoprotective potential of the fraction prepared from alcoholic extract was studied. Suresh kumar and mishra 2008 have also reported hepatoprotective effect of pergularia demia ethanol extract.
Hepatoprotective activity of ethanolic extract of eclipta. Hepatoprotective role of eclipta alba against high fatty diet. Kesharanjana, mochkand, bhangra plant introduction eclipta alba, the annual herbaceous plant, is also called as false daisy. Massage you underfeetheel skin with eclipta alba juice regularly to cure this pain. The most commonly used parameters to assess the hepatoprotective activity are morphological e. A histopathological study of the liver further suggest the hepatoprotective efficacy of eclipta alba extracts fig. The previous studies shows that hepatoprotective activity of eclipta alba is by regulating the levels of hepatic microsomal drug metabolizing enzymes saxena ak, et al. Jaya raju, investigation of hepatoprotective activity of spondias pinnata, international journal of pharma sciences and research, vol.
These herbal drugs have equivalent therapeutic value with the standards drug silymarin. Alcoholic extract of eclipta alba shows in vitro antioxidant. Hindi balari, bhangra, bhringraj, bhengra, mochkand, bhangaraiya. Plants free fulltext antifungal activity of eclipta alba.
Eclipta alba is being examined for its memory enhancing quality as it is traditionally used for this purpose. The herbal composition of present invention comprises extract of andrographis paniculata. Moreover, it is very important to study the specific phytochemical compounds responsible for this hepatoprotective effect. An alcoholic extract of freshly collected eclipta alba exhibited dosedependent 62. This has prompted the identification and development of ecofriendly greener alternatives. These findings suggest that methanol extract of eclipta alba may have potential as a hair growth promoter. Withania somnifera and eclipta alba ameliorate oxidative. Fengmin xi, chuntong li, junling mi, zhijun wu, wansheng chen. Unscientific use of synthetic fungicides in plant disease management has environmental ramifications, such as disease resurgence and serious health problems due to their carcinogenicity. In indian systems of medicines herbal decoction of eclipta alba is used for the treatment of liver cirrhosis, infective hepatitis liver inflammation due to a viral infection, liver enlargement, and other related diseases of liver and gall bladder 39. Tabassum n, agrawal ss 2004 hepatoprotective activity of eclipta alba hassk. Mar 21, 2017 since the time of ayurveda till today bhringraj eclipta alba is a topnotch herb used in hair care industry.
Hepatoprotective and cardiac inhibitory activities of. Evaluation of hepatorenal and haematological protection of ethanolic extract of eclipta alba in. Hepatoprotective effect of enicostemma littorale blume. Screening of leaves and roots of eclipta alba for hepatoprotective activity v. Liver disease is the major cause of serious health problem leading to morbidity and mortality worldwide and the problem has increased in search for hepatotherapeutic agents from plants.
Pharmacological activity and chemical constituents of. The hepatoprotective activity of olive oil and nigella. Eclipta alba extract was evaluated for its antifungal activity in in vitro and in vivo against sorghum fungal pathogens fusarium thapsinum, alternaria alternata, epicoccum sorghinum, and curvularia lunata. The effect of agnps was studied against fourth instar larvae of filariasis vector, culex quinquefasciatus and malaria vector anopheles subpictus grass rajakumar and abdul.
The plant eclipta alba linn hassk family asteraceae has been mentioned in ancient texts to be a nervine tonic in addition to possessing hepatoprotective, hair growth promoting and antiaging properties. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals. This plant is known to have various pharmacological activities and is traditionally used in treatment but it lacks adequate scientific proof of this activity and constituents responsible for it. Hepatoprotective effects of eclipta alba on subcellular. It appears to have preliminary evidence to suggest hair growth promotion as potent as minoxidil and some antidiabetic effects as well as liver protection. Jun 20, 2018 eclipta alba false daisy is a herb that has traditional usage as a liver tonic in ayurveda. Applied biochemistry and biotechnology 20, 171, 20032019. The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. Hepatoprotective activity of ethanolic extract of eclipta alba in albino rats. Its effect on mitochondrial succinate dehydrogenase and adenosine 5 triphosphatase was not significant. Similar hepatoprotective effects have also been reported in rabbits. Antibreast tumor activity of eclipta extract invitro and. In vivo hepatoprotective activity of active fraction from ethanolic extract of eclipta alba leaves. Eclipta alba supplement health benefits, dosage, side.
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